A drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and are at a high risk of developing breast cancer. Nolvadex is also being studied in the treatment of other types of cancer. It blocks the effects of the hormone estrogen in the breast. Nolvadex is a type of antiestrogen. Also called tamoxifen and tamoxifen citrate.