A monoclonal antibody being studied in the treatment of kidney cancer, melanoma, and pulmonary fibrosis. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. GC1008 binds to the protein transforming growth factor-beta (TGF?) and may block the growth of cancer cells that make it. Also called anti-TGF-beta monoclonal antibody GC1008.